Caspase-8 Substrate IETD-pNA

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• Catalog number
  1063-1000
• Price:

  599.4 USD

  Ask for price
• Size
  1000 assays

# #

• Alternative_name
  Ac-IETD-pNA, Caspase-8 Substrate, Colorimetric
• Description
  Ready-to-use colorimetric substrate for FLICE/caspase-8 and related caspases that recognize the amino acid sequence IETD. The sequence IETD is based on caspase-8 cleavage site in CPP32/Caspase-3 proenzyme. FLICE and related caspase activity can be quantified by spectrophotometric detection of free pNA (l= 400 nm) after cleavage from the peptide substrate IETD-pNA, using a spectrophotometer or multi-well plate reader.
• Structure Available
  No
• Peptide sequence
  Ac-Ile-Glu-Thr-Asp-pNA
• Salt Form
  No
• Molecular Formula
  C₂₇H₃₈N₆O₁₂
• Molecular Weight
  638.6
• Cell Permeable
  No
• Purity
  >95% by HPLC
• Handling
  Protect from light and moisture
• Tag Line
  A Caspase-8 substrate
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  12 months
• MDL Number
  MFCD01318840
• PubChem CID
  25108782
• PubChem CID Link
• SMILES
  CCC(C)C(C(=O)NC(CCC(=O)O)C(=O)NC(C(C)O)C(=O)NC(CC(=O)O)C(=O)NC1=CC=C(C=C1)[N+](=O)[O-])NC(=O)C
• InChi
  InChI=1S/C27H38N6O12/c1-5-13(2)22(28-15(4)35)26(42)30-18(10-11-20(36)37)24(40)32-23(14(3)34)27(43)31-19(12-21(38)39)25(41)29-16-6-8-17(9-7-16)33(44)45/h6-9,13-14,18-19,22-23,34H,5,10-12H2,1-4H3,(H,28,35)(H,29,41)(H,30,42)(H,31,43)(H,32,40)(H,36,37)(H,38,39)/t13-,14+,18-,19-,22-,23-/m0/s1
• InChi Key
  FHURKTIGZAIQGR-BQCLNCLCSA-N
• Data Sheet Link
• MSDS Available
  Yes
• Additional description
  Human and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways.

#

• Gene target
  Caspase-8   Substrate   IETD-pNA  
• Short name
  Caspase-8 Substrate IETD-pNA
• Alternative name
  caspase-8 Substrate IETD-pNA

MeSH Data

• Name
  Models, Chemical
• Concept
  Scope note: Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
• Tree numbers
  • E05.599.495

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